Article

Cell-autonomous and non-cell-autonomous effect of TRIM72 on ALS disease progression

2025-01-13

Abstract excerpt

Dysfunction of RNA-binding proteins, including TDP-43 and FUS, has been associated with amyotrophic lateral sclerosis (ALS); however, the underlying mechanisms are largely unknown. Here, we reported that a neuronal upregulation of TRIM72 (Tripartite Motif Containing 72) in FUS mutation knockin ALS models slows disease progression. TRIM72 interacts with Commander, a protein complex for recycling of membrane protein...

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Literature Corpus work: b4d6a0a4-8b11-5e0e-818f-c8a19c3cebe9
DOI: 10.1101/2025.01.09.632080

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