Article

VAPB Confers Selective Neuroprotection by Driving Autophagic Degradation of Pathogenic Aggregates in ALS

2026-01-06

Abstract excerpt

<title>Abstract</title> <p>(Acta Neuropathologica commun) During the progression of amyotrophic lateral sclerosis (ALS), only specific motor neurons (MNs) preferentially deteriorate, while others are spared until the disease reaches its end stage. Resilient MNs possess several protective factors, yet the precise molecular mechanism(s) underlying selective neuronal vulnerability remains poorly understood. Vesicle-...

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Literature Corpus work: ad19b701-895b-5a1f-86bc-5558f7226da6
DOI: 10.21203/rs.3.rs-8428187/v1

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