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Disruption of ER−mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis

28 Feb 2018

Abstract excerpt

Fronto-temporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two related and incurable neurodegenerative diseases. Features of these diseases include pathological protein inclusions in affected neurons with TAR DNA-binding protein 43 (TDP-43), dipeptide repeat proteins derived from the C9ORF72 gene, and fused in sarcoma (FUS) representing major constituent proteins in these inclusions. Mutations in...

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PMID: 29491392
DOI: 10.1038/s41419-017-0022-7

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