Article

Muscle cells of sporadic ALS patients secrete neurotoxic vesicles

2021-03-12

Abstract excerpt

<h4>Background</h4> The cause of the motor neuron (MN) death that drives terminal pathology in Amyotrophic Lateral Sclerosis (ALS) remains unknown, and it is thought that the cellular environment of the MN may play a key role in MN survival. Several lines of evidence implicate vesicles in ALS, including that extracellular vesicles may carry toxic elements from astrocytes towards motor neurons, and that pathologica...

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Literature Corpus work: a4dae08a-58a9-5ce0-aaa3-95b011be6ba4
DOI: 10.1101/2021.03.11.21252078

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