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Article

Cell to cell spreading of misfolded proteins as a therapeutic target in motor neuron disease.

Current medicinal chemistry - 1 Jan 2014

Pasquali Livia, Lenzi Paola, Biagioni Francesca, Siciliano Gabriele, Fornai Francesco

Abstract excerpt

Despite a number of genetic mutations and molecular mechanisms are recognized to participate in amyotrophic lateral sclerosis (ALS), such a devastating neurological disorder still lacks a substantial cure. The present manuscript rather than a general overview of potential therapeutic approaches focuses on novel research findings detailing novel molecular mechanisms which appear to be promising for developing...

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Identifiers

PMID: 24934358
DOI: 10.2174/0929867321666140601161534

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