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Article

M6A reduction relieves FUS-associated ALS granules.

Nature communications - 12 Jun 2024

Di Timoteo Gaia, Giuliani Andrea, Setti Adriano, Biagi Martina C, Lisi Michela, Santini Tiziana, Grandioso Alessia, Mariani Davide, Castagnetti Francesco, Perego Eleonora, Zappone Sabrina, Lattante Serena, Sabatelli Mario, Rotili Dante, Vicidomini Giuseppe, Bozzoni Irene

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease due to gradual motoneurons (MN) degeneration. Among the processes associated to ALS pathogenesis, there is the formation of cytoplasmic inclusions produced by aggregation of mutant proteins, among which the RNA binding protein FUS. Here we show that, in neuronal cells and in iPSC-derived MN expressing mutant FUS, such inclusions are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38866783
DOI: 10.1038/s41467-024-49416-5
PMCID: PMC11169559

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M6A reduction relieves FUS-associated ALS granules.PMID 38866783Read ↗

M <sup>6</sup> A reduction relieves FUS-associated ALS granulesSemantic proximity Read ↗

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