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Lost in local translation: TDP-43 and FUS in axonal/neuromuscular junction maintenance and dysregulation in amyotrophic lateral sclerosis.

Neuron - 3 May 2023

Piol Diana, Robberechts Tessa, Da Cruz Sandrine

Abstract excerpt

Key early features of amyotrophic lateral sclerosis (ALS) are denervation of neuromuscular junctions and axonal degeneration. Motor neuron homeostasis relies on local translation through controlled regulation of axonal mRNA localization, transport, and stability. Yet the composition of the local transcriptome, translatome (mRNAs locally translated), and proteome during health and disease remains largely...

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PMID: 36963381
DOI: 10.1016/j.neuron.2023.02.028

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