Article

Improving Motor Function in Amyotrophic Lateral Sclerosis: The impact of Triumeq on a TDP-43 mouse model

2025-09-03

Abstract excerpt

<title>Abstract</title> <p>Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by the accumulation of TAR DNA Binding Protein (43kDa; TDP-43) within the cytoplasm of neurons. Endogenous retroviruses (ERVs) have been implicated in ALS pathology and the application of antiretroviral therapy, specifically Triumeq, has been proposed for treatment of ALS. However, evidenc...

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Literature Corpus work: 15cf28da-95c6-5d8f-992f-486b74c1242a
DOI: 10.21203/rs.3.rs-7351593/v1

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