Article

iPSC Motor Neurons with Familial ALS Mutations Capture Gene Expression Changes in Postmortem Sporadic ALS Motor Neurons

2022-10-25

Abstract excerpt

Motor neuron degeneration, the defining feature of ALS, is a primary example of cell-type specificity in neurodegenerative diseases. Using isogenic pairs of iPSCs harboring different familial ALS mutations, we assess the capacity of iPSC-derived spinal motor neurons, sensory neurons, astrocytes, and superficial cortical neurons to capture disease features including transcriptional and splicing dysregulation observ...

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Literature Corpus work: 111e16d2-2748-5bb8-8d3c-e1e69f01acc3
DOI: 10.1101/2022.10.25.513780

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