Article

Gene Expression Signatures of Sporadic ALS Motor Neuron Populations

2016-02-01

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease primarily affecting motor neurons (MNs) to cause progressive paralysis. Ninety percent of cases are sporadic (sALS) and ten percent are familial (fALS). The molecular mechanisms underlying neurodegeneration remain elusive and there is a lack of promising biomarkers that define ALS phenotypes and progression. To date, most expression studies h...

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Literature Corpus work: 375b137f-f65f-5dc6-b816-20aa141f2496
DOI: 10.1101/038448

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