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Single-cell RNA sequencing across isogenic <i>FUS</i> and <i>TARDBP</i> ALS lines reveals a shared early mitochondrial dysfunction unique to motor neurons

2023-03-16

Abstract excerpt

Mutations in the RNA/DNA-binding proteins FUS and TDP-43 cause the fatal disease amyotrophic lateral sclerosis (ALS). The precise mechanisms behind the selective motor neuron degeneration remain unclear and it is uncertain if ALS-causative mutations trigger motor neuron death through shared or distinct pathogenic pathways. To address these two questions, we performed single-cell RNA sequencing across neuron types...

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Literature Corpus work
57e55ac4-1ff2-51cb-9fd2-aa0477765fe1
DOI
10.1101/2023.03.16.531876
Open publication

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Single-cell RNA sequencing across isogenic <i>FUS</i> and <i>TARDBP</i> ALS lines reveals a shared early mitochondrial dysfunction unique to motor neuronsDOI 10.1101/2023.03.16.531876
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