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Article

The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis

2019-07-02

Abstract excerpt

Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. Cul3 engages dozens of adaptor proteins to recruit hundreds of substrates for ubiquitination, but the adaptors that impact sleep and synapses remain ill-defined. Here we implicate Insomniac (Inc), a conserved protein required fo...

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Literature Corpus work
b49d4c80-7b41-5c35-a762-87f850f03f0c
DOI
10.1101/689471
Open publication

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The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasisDOI 10.1101/689471
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