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Article

Current trends of high-risk gene Cul3 in neurodevelopmental disorders

28 Jul 2023

Abstract excerpt

Cul3 encodes Cullin-3, a core component of the ubiquitin E3 ligase that is involved in protein ubiquitination. Recent studies have identified Cul3 as a high-confidence risk gene in neurodevelopmental disorders (NDDs), especially autism spectrum disorder (ASD). Different strategies have been used to generate animal models with Cul3 deficiency in the central nervous system, including whole-brain knockout (KO),...

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PMID: 37575562
DOI: 10.3389/fpsyt.2023.1215110

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