Article
A Drosophila model for Angelman syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2008
Wu Yaning, Bolduc Francois V, Bell Kimberly, Tully Tim, Fang Yanshan, Sehgal Amita, Fischer Janice A
Abstract excerpt
Angelman syndrome is a neurological disorder whose symptoms include severe mental retardation, loss of motor coordination, and sleep disturbances. The disease is caused by a loss of function of UBE3A, which encodes a HECT-domain ubiquitin ligase. Here, we generate a Drosophila model for the disease. The results of several experiments show that the functions of human UBE3A and its fly counterpart, dube3a, are...
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