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Article

insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila.

Neuron - 22 Dec 2011

Stavropoulos Nicholas, Young Michael W

Abstract excerpt

In a forward genetic screen in Drosophila, we have isolated insomniac, a mutant that severely reduces the duration and consolidation of sleep. Anatomically restricted genetic manipulations indicate that insomniac functions within neurons to regulate sleep. insomniac expression does not oscillate in a circadian manner, and conversely, the circadian clock is intact in insomniac mutants, suggesting that insomniac...

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Identifiers

PMID: 22196332
DOI: 10.1016/j.neuron.2011.12.003
PMCID: PMC3244879

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