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Article

The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis.

PLoS genetics - 1 Jan 2025

Li Qiuling, Lim Kayla Y, Altawell Raad, Verderose Faith, Li Xiling, Dong Wanying, Martinez Joshua, Dickman Dion, Stavropoulos Nicholas

Abstract excerpt

Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. Cul3 engages dozens of adaptor proteins to recruit hundreds of substrates for ubiquitination, but the adaptors that impact sleep and synapses remain ill-defined. Here we implicate Insomniac (Inc), a conserved protein required...

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Identifiers

PMID: 39841692
DOI: 10.1371/journal.pgen.1011574
PMCID: PMC11790235

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