Notch1 Signaling Contributed To TLR4-Triggered NF-kB Activation In Macrophages

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Macrophages substantially shape the development, progression, and complications of inflammation-driven diseases. Although numerous researches support a critical role for Notch signaling in most inflammatory diseases, there is limited data on the role of Notch signaling in TLR4-induced macrophage activation and the interaction of Notch signaling with other signal...

Topics

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• Cytokine Signaling Pathways and Interactions
• Drosophila melanogaster
• Immune Response and Inflammation
• Immunity, Innate
• Mammals
• NF-κB Signaling Pathways
• Polymorphism, Single Nucleotide
• Toll-Like Receptors

Identifiers and source

Literature Corpus work

bada4790-6140-5e1d-9c06-b67bdbaab373

DOI

10.21203/rs.3.rs-1081661/v1