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Article

The NLRP1 Inflammasome in Human Skin and Beyond

6 Jul 2020

Abstract excerpt

Inflammasomes represent a group of protein complexes that contribute to host defense against pathogens and repair processes upon the induction of inflammation. However, aberrant and chronic inflammasome activation underlies the pathology of numerous common inflammatory diseases. Inflammasome assembly causes activation of the protease caspase-1 which in turn activates proinflammatory cytokines and induces a lytic...

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PMID: 32640751
DOI: 10.3390/ijms21134788

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