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Diplotype analysis of NUDT15 using digital PCR in pediatric acute lymphoblastic leukemia

2025-09-02

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common form of pediatric leukemia in Japan and presents significant treatment challenges owing to variable patient sensitivity to the key therapeutic agent, 6-mercaptopurine. This variability is often linked to genetic differences, particularly variants of NUDT15 , which can lead to severe myelosuppression and an increased risk of second malignancies. Current methods...

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Literature Corpus work
b447ba88-d7db-59f1-a14c-75cccf1c917c
DOI
10.22541/au.175682174.44287819/v1
Open publication

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Diplotype analysis of NUDT15 using digital PCR in pediatric acute lymphoblastic leukemiaDOI 10.22541/au.175682174.44287819/v1
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