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Article

Diplotype analysis of NUDT15 using digital PCR in pediatric acute lymphoblastic leukemia

2026-01-08

Abstract excerpt

<title>Abstract</title> <p> Patients with <italic>NUDT15</italic> variants exhibit intolerance to 6-mercaptopurine (6-MP), which can cause severe myelosuppression and increase the risk of second malignancies, especially in those with bi-allelic variants. However, no reliable analytical method is available to determine the diplotype of <italic>NUDT15</italic> . Therefore, we aimed to develop a practical diplo...

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Literature Corpus work
4c3b2002-55af-5654-9ee2-b76db6cce3e9
DOI
10.21203/rs.3.rs-8438183/v1
Open publication

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Diplotype analysis of NUDT15 using digital PCR in pediatric acute lymphoblastic leukemiaDOI 10.21203/rs.3.rs-8438183/v1
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