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NUDT15 genetic variants are related to thiopurine-induced neutropenia in Thai children with acute lymphoblastic leukemia.

Pharmacogenomics - 1 Apr 2020

Puangpetch Apichaya, Tiyasirichokchai Rawiporn, Pakakasama Samart, Wiwattanakul Supaporn, Anurathapan Usanarat, Hongeng Suradej, Sukasem Chonlaphat

Abstract excerpt

Aim: 6-Mercaptopurine (6MP) is key to the treatment of acute lymphoblastic leukemia (ALL) as part of maintenance therapy. NUDT15 was identified as a novel thiopurine regulator conferring 6MP sensitivity. The aim of this study was to evaluate the influence of NUDT15 variants on 6MP-induced neutropenia in Thai children with ALL. Materials & methodology: Genotyping of NUDT15 (c.415C>T; rs116855232) and...

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Antimetabolites, Antineoplastic
Asian People
Infant
Mercaptopurine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Pyrophosphatases

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PMID: 32308129
DOI: 10.2217/pgs-2019-0177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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