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Article

Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients.

Scientific reports - 1 Sept 2020

Yu Chih-Hsiang, Chang Ya-Hsuan, Wang Der-Shiun, Jou Shiann-Tarng, Lin Chien-Yu, Lin Kai-Hsin, Lu Meng-Yao, Raghav Lovely, Chang Hsiu-Hao, Wu Kang-Hsi, Chou Shu-Wei, Ni Yu-Ling, Lin Dong-Tsamn, Lin Shu-Wha, Chen Hsuan-Yu, Yang Yung-Li

Abstract excerpt

Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric acute lymphoblastic leukemia. Recently, NUDT15 variants were identified as a major determinant of mercaptopurine intolerance. Two NUDT15 variants, c.36_37insGGAGTC and c.415C > T, are located on exons 1 and 3, respectively. Patients with heterozygous c.36_37insGGAGTC and c.415C > T can be either compound heterozygous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32873882
DOI: 10.1038/s41598-020-71468-y
PMCID: PMC7463237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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