Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia.

Cancer research and treatment - 1 Jul 2018

Yi Eun Sang, Choi Young Bae, Choi Rihwa, Lee Na Hee, Lee Ji Won, Yoo Keon Hee, Sung Ki Woong, Lee Soo-Youn, Koo Hong Hoe

Abstract excerpt

PURPOSE: We aimed to identify the impact of NUDT15 variants on thiopurine intolerance and 6-thioguanine nucleotide (6-TGN) levels in Korean children with acute lymphoblastic leukemia (ALL). MATERIALS AND METHODS: Genotyping of NUDT15 was tested in 258 patients with ALL registered at Samsung Medical Center. Patients were classified into normal-activity (wild-type), intermediate-activity (heterozygous variant), and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Administration Schedule
Share to Guanine Nucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mercaptopurine

Share to Pharmacogenomic Variants

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Pyrophosphatases

Share to Republic of Korea

Share to Thionucleotides

Source

Open in PubMed Open full text

Identifiers

PMID: 28903549
DOI: 10.4143/crt.2017.283
PMCID: PMC6056957

Genes

NUDT15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia.PMID 28903549Read ↗

NUDT15 genetic variants are related to thiopurine-induced neutropenia in Thai children with acute lymphoblastic leukemia.Semantic proximity Read ↗

NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine.Semantic proximity Read ↗

Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry.Semantic proximity Read ↗

DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes.Semantic proximity Read ↗

NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine TherapySemantic proximity Read ↗

The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?Semantic proximity Read ↗

Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age.Semantic proximity Read ↗

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.Semantic proximity Read ↗

Emerging role of NUDT15 polymorphisms in 6-mercaptopurine metabolism and dose related toxicity in acute lymphoblastic leukaemia.Semantic proximity Read ↗

Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

NUDT15 Polymorphism and Its Association With Mercaptopurine Hematotoxicity in Acute Lymphoblastic Leukemia in Indonesian Children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.