Prevalence of TPMT and NUDT15 diplotypes in Mexican children with B-cell acute lymphoblastic leukemia.

doi:10.1097/FPC.0000000000000593

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Prevalence of TPMT and NUDT15 diplotypes in Mexican children with B-cell acute lymphoblastic leukemia.

Pharmacogenetics and genomics - 1 Jul 2026

Garcia-Solorio Joaquin, Molina-Garay Carolina, Sánchez-Martínez Víctor Jesús, Villegas-Torres Beatriz Eugenia, Campos-Perez Irlanda, Jiménez-Olivares Marco, Flores-Espino Fernanda, Casique-Aguirre Diana, Núñez-Enriquez Juan Carlos, Flores-Lujano Janet, Mata-Rocha Minerva, Peñaloza-Gonzalez José Gabriel, Olivares-Villalpando Victor Hugo, Baños-Lara Ma Del Rocío, García-Soto Ángel, Galván-Díaz César Alejandro, Olaya-Vargas Alberto, Solano-Cardozo Moises, Garrido-Hernández Miguel Ángel, Luna-Silva Nuria Citlalli, Cano-Cuapio Lena Sarahi, Carrillo-Sanchez Karol, Flores-Lagunes Luis Leonardo, Mendoza-Caamal Elvia Cristina, González-Osnaya Vincent, Pelayo-Camacho Rosana, Mejía-Arangure Juan Manuel, Yang Jun J, Alaez-Verson Carmen

Abstract excerpt

OBJECTIVE: To characterize the allelic and diplotype variability of TPMT and NUDT15 in pediatric patients with B-cell acute lymphoblastic leukemia from the central-southern region of Mexico. METHODS: Samples from 275 pediatric B-cell acute lymphoblastic leukemia patients were analyzed. Next-generation sequencing was used for TPMT and NUDT15 genotyping. Alleles and diplotypes were assessed according to the...

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Identifiers

PMID: 41630471
DOI: 10.1097/FPC.0000000000000593
PMCID: PMC13200876

Genes

TPMT
NUDT15

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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