Article

Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial-immune cell interactions

2025-12-23

Abstract excerpt

The distal small intestine plays vital roles in host physiology by regulating nutrient and fluid homeostasis. Despite being impacted in Crohn’s disease and a major target for a range of infections, we know relatively little about the complexity of cellular responses and cell-cell communication in the ileum during infection. Single cell and spatial transcriptomics have emerged as powerful technologies to study tiss...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4458fa5-c66a-5a90-b246-aca51958c507
DOI: 10.64898/2025.12.22.695505

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial-immune cell interactionsDOI 10.64898/2025.12.22.695505Read

Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac diseaseSemantic proximity Read

Single-cell transcriptomics reveals immune response of intestinal cell types to viral infectionSemantic proximity Read

Organization of the human intestine at single-cell resolutionSemantic proximity Read

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn’s diseaseSemantic proximity Read

The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonSemantic proximity Read

The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonSemantic proximity Read

High Resolution Single Cell Maps Reveals Distinct Cell Organization and Function Across Different Regions of the Human IntestineSemantic proximity Read

Single-Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells From Ulcerative Colitis Patients.Semantic proximity Read

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe diseaseSemantic proximity Read

Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gutSemantic proximity Read

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn’s Disease PathogenesisSemantic proximity Read

Regional Cell Atlas of Human Intestine Shapes Distinct Immune SurveillanceSemantic proximity Read