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Article

Single-Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells From Ulcerative Colitis Patients.

Gastroenterology - 1 Apr 2021

Devlin Joseph C, Axelrad Jordan, Hine Ashley M, Chang Shannon, Sarkar Suparna, Lin Jian-Da, Ruggles Kelly V, Hudesman David, Cadwell Ken, Loke P'ng

Abstract excerpt

BACKGROUND & AIMS: Restorative proctocolectomy with ileal pouch-anal anastomosis is a surgical procedure in patients with ulcerative colitis refractory to medical therapies. Pouchitis, the most common complication, is inflammation of the pouch of unknown etiology. To define how the intestinal immune system is distinctly organized during pouchitis, we analyzed tissues from patients with and without pouchitis and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33359089
DOI: 10.1053/j.gastro.2020.12.030
PMCID: PMC8327835

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