Article

Mutant p53 <sup>R175H</sup> -Associated Protection of Ovarian Cancer Precursor Cells from Cisplatin Requires Expression of SLC6A6 Taurine Transporter

2025-01-03

Abstract excerpt

<h4>ABSTRACT</h4> Tumor suppressor gene TP53 is ubiquitously mutated in ovarian cancer precursor lesions that undergo pervasive accumulation of DNA damage. Prior literature provides evidence that the expression of mutant p53 protein in epithelial cells is associated with increased survival in response to DNA-damaging treatments. Hence, identification and understanding of the mechanisms that, in response to DNA da...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4308802-a80c-5343-a3bf-155b4a7f396e
DOI: 10.1101/2025.01.03.631237

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutant p53 <sup>R175H</sup> -Associated Protection of Ovarian Cancer Precursor Cells from Cisplatin Requires Expression of SLC6A6 Taurine TransporterDOI 10.1101/2025.01.03.631237Read

Gain-of-function p53 R175H blocks apoptosis in a precursor model of ovarian high-grade serous carcinomaSemantic proximity Read

Human fallopian tube epithelial organoids with TP53 mutation recapitulate features of serous tubal intraepithelial carcinoma (STIC).Semantic proximity Read

Human Fallopian Tube-Derived Organoids with TP53 and RAD51D Mutations Recapitulate an Early Stage High-Grade Serous Ovarian Cancer Phenotype In Vitro.Semantic proximity Read

<i>TP53</i> loss initiates chromosomal instability in high-grade serous ovarian cancerSemantic proximity Read

p53 protein aggregation promotes platinum resistance in ovarian cancer.Semantic proximity Read

TP53 loss initiates chromosomal instability in fallopian tube epithelial cells.Semantic proximity Read

Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface.Semantic proximity Read

A candidate precursor to serous carcinoma that originates in the distal fallopian tube.Semantic proximity Read

Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase etaSemantic proximity Read

Serine/Threonine Kinase 17A Is a Novel p53 Target Gene and Modulator of Cisplatin Toxicity and Reactive Oxygen Species in Testicular Cancer CellsSemantic proximity Read

Rescue of p53 functions by in vitro‐transcribed mRNA impedes the growth of high‐grade serous ovarian cancerSemantic proximity Read

Spontaneous Single-Copy Loss of TP53 in Human Embryonic Stem Cells Markedly Increases Cell Proliferation and Survival.Semantic proximity Read