Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human fallopian tube epithelial organoids with TP53 mutation recapitulate features of serous tubal intraepithelial carcinoma (STIC).

Gynecologic oncology - 1 Dec 2025

Kraiczy Judith, Yu Bo

Abstract excerpt

OBJECTIVE: Serous tubal intraepithelial carcinoma (STIC) is the immediate precursor lesion for high-grade serous ovarian carcinoma (HGSOC) and harbors universal TP53 mutations. The lack of an appropriate in vitro model for STIC presents a major challenge in studying its pathogenesis. We aimed to develop a human in vitro model that mimics STIC lesions. METHODS: Using CRISPR-Cas9 gene editing, we generated human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma in Situ
Share to CRISPR-Cas Systems
Share to Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Fallopian Tube Neoplasms

Share to Fallopian Tubes

Share to Gene Editing

Share to Organoids

Source

Open in PubMed Open full text

Identifiers

PMID: 41270297
DOI: 10.1016/j.ygyno.2025.10.038
PMCID: PMC12767781

Genes

TP53
FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human fallopian tube epithelial organoids with TP53 mutation recapitulate features of serous tubal intraepithelial carcinoma (STIC).PMID 41270297Read ↗

High grade serous ovarian carcinomas originate in the fallopian tube.Semantic proximity Read ↗

<i>TP53</i> loss initiates chromosomal instability in high-grade serous ovarian cancerSemantic proximity Read ↗

Gain-of-function p53 R175H blocks apoptosis in a precursor model of ovarian high-grade serous carcinomaSemantic proximity Read ↗

Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation.Semantic proximity Read ↗

Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma.Semantic proximity Read ↗

Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids.Semantic proximity Read ↗

Human Fallopian Tube-Derived Organoids with TP53 and RAD51D Mutations Recapitulate an Early Stage High-Grade Serous Ovarian Cancer Phenotype In Vitro.Semantic proximity Read ↗

Next-Generation Sequencing of Tubal Intraepithelial Carcinomas.Semantic proximity Read ↗

TP53 loss initiates chromosomal instability in fallopian tube epithelial cells.Semantic proximity Read ↗

TP53 variants in p53 signatures and the clonality of STICs in RRSO samples.Semantic proximity Read ↗

In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cellsSemantic proximity Read ↗

Both Fallopian Tube and Ovarian Surface Epithelium Can Act as Cell-of-Origin for High Grade Serous Ovarian CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.