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Article

Human Fallopian Tube-Derived Organoids with TP53 and RAD51D Mutations Recapitulate an Early Stage High-Grade Serous Ovarian Cancer Phenotype In Vitro.

International journal of molecular sciences - 10 Jan 2024

Dai Yilin, Xu Jing, Gong Xiaofeng, Wei Jinsong, Gao Yi, Chai Ranran, Lu Chong, Zhao Bing, Kang Yu

Abstract excerpt

RAD51D mutations have been implicated in the transformation of normal fallopian tube epithelial (FTE) cells into high-grade serous ovarian cancer (HGSOC), one of the most prevalent and aggressive gynecologic malignancies. Currently, no suitable model exists to elucidate the role of RAD51D in disease initiation and progression. Here, we established organoids from primary human FTE and introduced TP53 as well as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38255960
DOI: 10.3390/ijms25020886
PMCID: PMC10815309

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Human Fallopian Tube-Derived Organoids with TP53 and RAD51D Mutations Recapitulate an Early Stage High-Grade Serous Ovarian Cancer Phenotype In Vitro.PMID 38255960Read ↗

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