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Article

TP53 loss initiates chromosomal instability in fallopian tube epithelial cells.

Disease models & mechanisms - 1 Nov 2021

Bronder Daniel, Tighe Anthony, Wangsa Darawalee, Zong Dali, Meyer Thomas J, Wardenaar René, Minshall Paul, Hirsch Daniela, Heselmeyer-Haddad Kerstin, Nelson Louisa, Spierings Diana, McGrail Joanne C, Cam Maggie, Nussenzweig André, Foijer Floris, Ried Thomas, Taylor Stephen S

Abstract excerpt

High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN). However, direct causes of CIN, such as mutations in DNA replication and mitosis genes, are rare in HGSOC. We therefore asked whether oncogenic mutations that are common in HGSOC can indirectly drive CIN in non-transformed human fallopian...

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Share to Chromosomal Instability
Share to Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34569598
DOI: 10.1242/dmm.049001
PMCID: PMC8649171

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