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Article

Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface.

Oncotarget - 25 Oct 2016

Karthikeyan Subbulakshmi, Lantvit Daniel D, Chae Dam Hee, Burdette Joanna E

Abstract excerpt

High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy and may arise in either the fallopian tube epithelium (FTE) or ovarian surface epithelium (OSE). A mutation in p53 is reported in 96% of HGSOC, most frequently at R273 and R248. The goal of this study was to identify specific gene targets in the FTE that are altered by mutant p53, but not in the OSE. Gene analysis revealed that...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27563818
DOI: 10.18632/oncotarget.11499
PMCID: PMC5342521

Genes

CDH6
FOXM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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