Article

Prolonged anesthesia alters brain synaptic architecture

2019-12-02

Abstract excerpt

<h4>SUMMARY</h4> Prolonged medically-induced coma (pMIC), a procedure performed in millions of patients worldwide, leads to cognitive impairment, yet the underlying brain mechanism remains unknown. No experimental studies of medically-induced coma (MIC) exceeding ~6 hours exist. For MIC of less than 6 hours, studies in developing rodents have documented transient changes of cortical synapse formation. However, in...

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Literature Corpus work: d4f06f32-1e25-578e-8f01-a00fa35f700c
DOI: 10.1101/862334

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