Article

Memory trace superimposition impairs recall in a mouse model of AD

2018-11-09

Abstract excerpt

<h4>Summary</h4> Learning and memory processes depend on the hippocampus and are impaired in Alzheimer’s disease (AD). Active neuronal ensembles form an engram by encoding information during learning. Their reactivation is required for memory recall. However, it remains unresolved whether the engram in CA1 principal neurons is impaired under AD-like conditions. We used two-photon in vivo imaging to visualize the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b454c7c8-997a-5554-ab5f-f15c4c05f2d4
DOI: 10.1101/467043

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Memory trace superimposition impairs recall in a mouse model of ADDOI 10.1101/467043Read

Remembering the gist of an event over a lifetime depends on the hippocampusSemantic proximity Read

One-shot memory in hippocampal CA3 networks.Semantic proximity Read

Remote memory engrams are controlled by encoding-specific tau phosphorylationSemantic proximity Read

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model.Semantic proximity Read

Spatial coding defects of hippocampal neural ensemble calcium activities in the 3xTg-AD Alzheimer’s disease mouse modelSemantic proximity Read

Misclassification in memory modification in <i> App <sup>NL-G-F</sup> </i> knock-in mouse model of Alzheimer’s diseaseSemantic proximity Read

Intermediate CA1 is Required for Object-in-Place Recognition Memory in MiceSemantic proximity Read

Autophagy in DG engrams mediates Rac1-dependent forgetting via TLR2/4 signals in microgliaSemantic proximity Read

Learning induces persistent chromatin loops underlying robust gene expression during memory recallSemantic proximity Read

Unconstrained Plasticity Disrupts Memory Consolidation in a Mouse Model of Rett SyndromeSemantic proximity Read

Tag-and-Trigger: Basolateral Amygdala Stimulation Reinforces Behaviorally Tagged Hippocampus-Cortical Circuits to Enhance Memory Consolidation and Reverse Alzheimer's Disease Pathology in 5XFAD MiceSemantic proximity Read

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse modelSemantic proximity Read