Article

Aromatase in adipose tissue exerts an osteoprotective function in male mice via phosphate regulation

2024-06-26

Abstract excerpt

Aromatase contributes to maintenance of bone mass because male patients with loss-of-function mutations of CYP19A1 exhibit bone loss. Treatment with aromatase inhibitor also causes bone loss in men and post-menopausal women, suggesting that part of the anabolic effect of testosterone in men is dependent on estradiol (E2) biosynthesized by aromatase in non-gonadal tissues. It remains unclear how locally biosynthes...

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Literature Corpus work: b40674c4-633e-519b-a14a-b0f784c60bd3
DOI: 10.1101/2024.06.24.600344

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