Article
Of mice and men: the evolving phenotype of aromatase deficiency.
Trends in endocrinology and metabolism: TEM - 1 Mar 2006
Jones Margaret E E, Boon Wah Chin, Proietto Joseph, Simpson Evan R
Abstract excerpt
We are rapidly becoming aware of the importance of estrogen in maintaining virtually all facets of male health. In order for estrogens to be synthesized endogenously, the enzyme responsible for their synthesis from androgens, aromatase, must be functional. The seven known men in whom aromatase is nonfunctional all have a mutation in either exon V or IX of the CYP19 gene, which encodes aromatase. Collectively,...
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