Article

Coordinated changes in gene expression, H1 variant distribution and genome 3D conformation in response to H1 depletion

2021-02-13

Abstract excerpt

Up to seven members of the histone H1 family may contribute to chromatin compaction and its regulation in human somatic cells. In breast cancer cells, knock-down of multiple H1 variants deregulates many genes, promotes the appearance of genome-wide accessibility sites and triggers an interferon response via activation of heterochromatic repeats. However, how these changes in the expression profile relate to the re...

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Literature Corpus work: b401769e-b84e-5939-a2c6-46fef7c12604
DOI: 10.1101/2021.02.12.429879

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