Article

Exercise and disease state influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the <i> SOD1 <sup>G93A</sup> </i> amyotrophic lateral sclerosis (ALS) mouse model

2024-07-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative disease. Accumulating evidence strongly suggests that intrinsic muscle defects exist and contribute to disease progression, including imbalances in whole-body metabolic homeostasis. We have previously reported that tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and fibro...

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Literature Corpus work: b3fe19f7-3018-5d89-b114-a86f75343534
DOI: 10.1101/2024.07.05.602199

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Exercise and disease state influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the <i> SOD1 <sup>G93A</sup> </i> amyotrophic lateral sclerosis (ALS) mouse modelDOI 10.1101/2024.07.05.602199Read

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