Article

Muscle-targeted Klotho Gene Therapy Ameliorates ALS Hallmarks by Addressing Multiple Disease Mechanisms in SOD1G93A Mice

2024-06-07

Abstract excerpt

<title>Abstract</title> <p>The antiaging protein a-Klotho (KL) exhibits neuroprotective and myoregenerative properties, mitigating age-related neurodegeneration and promoting muscle regeneration. This study harnesses its pleiotropic properties in the context of Amyotrophic Lateral Sclerosis (ALS), a motoneuron disease lacking effective treatments due to its diverse pathophysiological mechanisms. By overexpressing...

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Literature Corpus work: 621f62de-4d10-5117-a59a-f1c1afb71979
DOI: 10.21203/rs.3.rs-4510655/v1

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