Article

Dysregulation of the Tweak/Fn14 pathway in skeletal muscle of spinal muscular atrophy mice

2021-09-15

Abstract excerpt

<h4>ABSTRACT</h4> Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN) protein. SMA is characterized by the selective death of spinal cord motor neurons, leading to progressive muscle wasting. Loss of skeletal muscle in SMA is a combination of denervation-induced muscle atrophy and intrinsic muscle pathologies. Elucidation of the pathways invol...

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Literature Corpus work: 1dd8acc6-f348-560b-b5f7-930b5aa8bc06
DOI: 10.1101/2021.09.13.460053

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