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Article

Running and swimming prevent the deregulation of the BDNF/TrkB neurotrophic signalling at the neuromuscular junction in mice with amyotrophic lateral sclerosis.

Cellular and molecular life sciences : CMLS - 1 Aug 2020

Just-Borràs Laia, Hurtado Erica, Cilleros-Mañé Víctor, Biondi Olivier, Charbonnier Frédéric, Tomàs Marta, Garcia Neus, Tomàs Josep, Lanuza Maria A

Abstract excerpt

Nerve-induced muscle contraction regulates the BDNF/TrkB neurotrophic signalling to retrogradely modulate neurotransmission and protect the neuromuscular junctions and motoneurons. In muscles with amyotrophic lateral sclerosis, this pathway is strongly misbalanced and neuromuscular junctions are destabilized, which may directly cause the motoneuron degeneration and muscular atrophy observed in this disease. Here,...

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Identifiers

PMID: 31646358
DOI: 10.1007/s00018-019-03337-5
PMCID: PMC11104938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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