Myostatin knockout mice increase oxidative muscle phenotype as an adaptive response to exercise.

Abstract excerpt

Myostatin-deficient mice (MSTN (-/-)) display excessive muscle mass and this is associated with a profound loss of oxidative metabolic properties. In this study we analysed the effect of two endurance-based exercise regimes, either a forced high-impact swim training or moderate intensity voluntary wheel running on the adaptive properties of the tibialis anterior and plantaris muscle from MSTN (-/-) mice. MSTN...

Topics

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• Adaptation, Physiological
• Hypertrophy
• Mice, Knockout
• Muscle, Skeletal
• Myosins