Article

Structural and functional studies of the Apical Sodium Dependent Bile Acid Transporter

2015-01-01

Abstract excerpt

The apical sodium dependent transporter (ASBT) is responsible for the uptake of bile acids from the apical membrane of the ileum cell. Loss of function mutations of ASBT relate to several diseases, such as Crohn's disease and Primary Bile Acid Malabsorption (PBAM). It is also a target for drugs aimed at lowering cholesterol. The X-ray crystal structure of a bacterial homologue of ASBT, ASBTNM, was previously solve...

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Literature Corpus work: b3f23ece-ff15-5f3a-bef9-73b0c238761b
DOI: 10.25560/30646

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