Article
Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2).
Journal of gastroenterology and hepatology - 1 Dec 2011
Ho Richard H, Leake Brenda F, Urquhart Brad L, Gregor Jamie C, Dawson Paul A, Kim Richard B
Abstract excerpt
BACKGROUND AND AIM: The major transporter responsible for bile acid uptake from the intestinal lumen is the apical sodium-dependent bile acid transporter (ASBT, SLC10A2). Analysis of the SLC10A2 gene has identified a variety of sequence variants including coding region single nucleotide polymorphisms (SNPs) that may influence bile acid homeostasis/intestinal function. In this study, we systematically...
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