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Article

Dissecting the Conformational Dynamics of the Bile Acid Transporter Homologue ASBTNM.

Journal of molecular biology - 19 Feb 2021

Lu Pei-Hua, Li Chieh-Chin, Chiang Yun-Wei, Liu Jyung-Hurng, Chiang Wesley Tien, Chao Yi-Hsuan, Li Guan-Syun, Weng Shao-En, Lin Sung-Yao, Hu Nien-Jen

Abstract excerpt

Apical sodium-dependent bile acid transporter (ASBT) catalyses uphill transport of bile acids using the electrochemical gradient of Na+ as the driving force. The crystal structures of two bacterial homologues ASBTNM and ASBTYf have previously been determined, with the former showing an inward-facing conformation, and the latter adopting an outward-facing conformation accomplished by the substitution of the...

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PMID: 33359100
DOI: 10.1016/j.jmb.2020.166764

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