Article

Structural insight into sodium-dependent bile acid transport by members of the SLC10 family

2026-02-20

Abstract excerpt

ASBT and NTCP are sodium-coupled secondary transporters of the SLC10 family that play critical roles in the enterohepatic recycling of bile acids. Secondary transporters generally function through the alternating access mechanism. However, in outward-facing structures of NTCP this mechanism is violated with a pore running through the protein. No such pore is observed in previously reported structures of bacterial...

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Literature Corpus work: 5e2241f4-04dc-5885-829e-e6e7b318b4a7
DOI: 10.64898/2026.02.20.706973

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