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Article

The noncanonical nucleotide binding site 1 of the bile salt export pump is optimized for proper function of the transporter.

Cell biology international - 1 May 2024

Sohail Imran, Hassan Mahmood Ul, Schmid Diethart, Chiba Peter

Abstract excerpt

The bile salt export pump (ABCB11/BSEP) is a hepatocyte plasma membrane-resident protein translocating bile salts into bile canaliculi. The sequence alignment of the four full-length transporters of the ABCB subfamily (ABCB1, ABCB4, ABCB5 and ABCB11) indicates that the NBD-NBD contact interface of ABCB11 differs from that of other members in only four residues. Notably, these are all located in the noncanonical...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 11
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38328902
DOI: 10.1002/cbin.12136

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