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Article

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.

PloS one - 1 Jan 2016

Xu Shuhua, Soroka Carol J, Sun An-Qiang, Backos Donald S, Mennone Albert, Suchy Frederick J, Boyer James L

Abstract excerpt

The heteromeric membrane protein Organic Solute Transporter alpha/beta is the major bile acid efflux transporter in the intestine. Physical association of its alpha and beta subunits is essential for their polarized basolateral membrane localization and function in the transport of bile acids and other organic solutes. We identified a highly conserved acidic dileucine motif (-EL20L21EE) at the extracellular...

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Identifiers

PMID: 27351185
DOI: 10.1371/journal.pone.0158269
PMCID: PMC4924846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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