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Article

The immune microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia

31 Mar 2022

Abstract excerpt

In chronic lymphocytic leukemia (CLL), B-cell receptor signaling, tumor-microenvironment interactions, and somatic mutations drive disease progression. To better understand the intersection between the microenvironment and molecular events in CLL pathogenesis, we integrated bulk transcriptome profiling of paired peripheral blood (PB) and lymph node (LN) samples from 34 patients. Oncogenic processes were...

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PMID: 35358998
DOI: 10.1182/bloodadvances.2021006941

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