Back to search

Article

NLRP3 controls ATM activation in response to DNA damage

2020-05-14

Abstract excerpt

<h4>ABSTRACT</h4> The DNA damage response (DDR) is essential to preserve genomic integrity and acts as a barrier to cancer. The ATM pathway orchestrates the cellular response to DNA double strand breaks (DSBs), and its attenuation is frequent during tumorigenesis. Here, we show that NLRP3, a Pattern Recognition Receptor known for its role in the inflammasome complex formation, interacts with the ATM kinase to con...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b3e4393f-2c06-5644-836d-0259f4ae09dc
DOI
10.1101/2020.05.12.087015
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
NLRP3 controls ATM activation in response to DNA damageDOI 10.1101/2020.05.12.087015
The NLRP1 inflammasome emerges as a promising therapeutic target and prognostic biomarker across multiple cancer types: A comprehensive pan-cancer analysisSemantic proximity
Differential role of the NLRP 3 inflammasome in infection and tumorigenesisSemantic proximity
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3Semantic proximity
Complex engagement of DNA damage response pathways in human cancer and in lung tumor progressionSemantic proximity
Histone demethylase KDM4B epigenetically controls NLRP3 expression to enhance inflammatory responsesSemantic proximity
NLRP3 inflammasome in cancer and metabolic diseasesSemantic proximity
Role of inflammasomes in cancer immunity: mechanisms and therapeutic potentialSemantic proximity
NLRP10 Cleaves Oxidized DNA inhibited by OGG1 inhibitors: A Newly Identified Role in DNA Damage Processing and Senescence RegulationSemantic proximity
NLRP3 Inflammasome Activation in Cancer: A Double-Edged SwordSemantic proximity
Posttranslational modifications of NLRP3 and their regulatory roles in inflammasome activationSemantic proximity
[Regulation of the NLRP3 inflammasome].Semantic proximity
Human NLRP1 and NLRP3 interact to drive inflammation in inflammosomopathies and inflammatory diseasesSemantic proximity
Select a neighboring publication to make it the new centre.