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Role of inflammasomes in cancer immunity: mechanisms and therapeutic potential

29 Mar 2025

Abstract excerpt

Inflammasomes are multi-protein complexes that detect pathogenic and damage-associated molecular patterns, activating caspase-1, pyroptosis, and the maturation of pro-inflammatory cytokines such as IL-1β and IL-18Within the tumor microenvironment, inflammasomes like NLRP3 play critical roles in cancer initiation, promotion, and progression. Their activation influences the crosstalk between innate and adaptive...

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Share to Immune Cell Function and Interaction
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PMID: 40155968
DOI: 10.1186/s13046-025-03366-y

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